Table 1.
Study Demographic Information Across Renal Function Groups in the Clinical Study
| Demographic Characteristic | Normal Renal Function (n = 10) | Severe Renal Impairment (n = 8) | ESRD (n = 8) |
|---|---|---|---|
| Age, y, median (range) | 62.5 (44.0‐76.0) | 73.0 (56.0‐80.0) | 55.0 (41.0‐62.0) |
| Height, cm, median (range) | 173 (163‐185) | 170 (156‐188) | 174 (161‐188) |
| Weight, kg, median (range) | 84.7 (72.7‐106.5) | 89.5 (66.1‐99.7) | 96.7 (75.0‐124.7) |
| BMI, kg/m2, median (range) | 29.60 (23.6‐37.0) | 29.55 (25.8‐36.8) | 30.45 (26.3‐37.7) |
| Sex, n (%) | |||
| Male | 6 (60.0) | 5 (62.5) | 5 (62.5) |
| Female | 4 (40.0) | 3 (37.5) | 3 (37.5) |
| Race, n (%) | |||
| White | 4 (40.0) | 7 (87.5) | 1 (12.5) |
| African American | 5 (50.0) | 1 (12.5) | 7 (87.5) |
| Asian | 0 | 0 | 0 |
| Other | 1 (10.0) | 0 | 0 |
| eGFR at check‐in, mL/min/1.73 m2, median (range) | 96.5 (88‐125) | 28 (13‐32)a | 7.0 (5.0‐7.0) |
BMI, body mass index; eGFR, estimated glomerular filtration rate; ESRD, end‐stage renal disease.
a
Classification of participants was based on values at screening. One subject in the severe group had an eGFR of 27 mL/min/1.73 m2 at screening, which shifted to 32 mL/min/1.73 m2 at check‐in.