Figure 5.

Endothelial cell‐cardiomyocyte crosstalk during ischaemia

Secreted molecules mediate a bidirectional signalling between adult endothelial cells (labelled by anti‐CD31 antibodies in green) and cardiomyocytes (labelled by anti‐α‐actinin antibodies in red) upon ischaemia. Nuclei are stained in blue by DAPI. The dashed arrows indicate the direction of the signals. Molecules secreted by endothelial cells are indicated on the left, while those secreted by both cell types are in the middle. Molecules acting in autocrine manner are indicated by curved arrows. Ang1, angiopoietin‐1; Fstl1, follistatin‐like 1; NRG‐1, neuregulin‐1; PDGF, platelet‐derived growth factor; TGF‐β, transforming growth factor β.