Figure 3.

Breast milk mediates the inhibition of infant CHS and the induction of TRAIL on pDCs. (A) Experimental design for cross‐fostering. For each group of infant mice, cross‐fostering was established within 48 h after birth, and pups were fed for 2 weeks by foster dams. (B) Ear swelling in pups was evaluated at 48 h after DNFB challenge (n = 6 [birth mother, Soy; foster dam, Soy] or 11 [birth mother, Soy; foster dam, Lin]). Horizontal lines indicate median values. P values were obtained by using the Mann‐Whitney U test (**P < .01). Data are representative of two independent experiments with reproducible results. (C) The ratio of TRAIL expression on dermal pDCs in pups was evaluated at 48 h after DNFB challenge. Horizontal lines indicate median values. P values were obtained by using the Mann‐Whitney U test (*P < .05). Data are pooled from two independent experiments with reproducible results