Figure 5.

Overexpression of FBXW7 attenuates CLP‐induced liver injury in mice. (a) H&E staining analysis of liver sections at a magnification of 200×. (b) Determination of liver injury according to portal inflammation scores, *p < .01 versus sham+AAV‐vector, ^# p < .01 versus Model+AAV‐vector. (c) qRT‐PCR analysis of Bax and Bcl‐2 levels in mice liver after 21‐day infection with adreno‐associated virus (AAV), *p < .01 versus sham+AAV‐vector, ^# p < .01 versus Model+AAV‐vector. (d) Western blot analysis of Bax and Bcl‐2 levels in mice liver after 21‐day infection with AAV. (e) qRT‐PCR analysis of TNF‐α, IL‐1β, and IL‐6 expression in mice liver after 21‐day infection with AAV, *p < .01 versus sham+AAV‐vector, ^# p < .01 versus Model+AAV‐vector. (f) Western blot analysis of TNF‐α, IL‐1β, and IL‐6 expression in mice liver after 21‐day infection with AAV. (g) qRT‐PCR analysis of CAT, GSH, and SOD1 expression in mice liver after 21‐day infection with AAV, *p < .01 versus sham+AAV‐vector, ^# p < .01 versus Model+AAV‐vector. (h) Western blot analysis of CAT, GSH, and SOD1 expression in mice liver after 21‐day infection with AAV. AAV, adreno‐associated virus; CAT, catalase; GAPDH, glyceraldehyde‐3‐phosphate dehydrogenase; GSH, glutathione; H&E, hematoxylin‐eosin; IL, interleukin; mRNA, messenger RNA; qRT‐PCR, quantitative reverse‐transcription polymerase chain reaction; SOD1, superoxide dismutase 1; TNF‐α, tumor necrosis factor‐α