TABLE 2.
AR vs TX 36‐gene model
| (A) Differential gene expression | ||||
|---|---|---|---|---|
| Model probe | Symbol | Entrez gene name | Log fold change (AR/TX) | Log fold change (AR/ADNR) |
| 227671_PM_at | XIST | X inactive specific transcript | 2.556868022 | 1.325410826 |
| 205654_PM_at | C4BPA | complement component 4 binding protein alpha | 1.101224469 | 0.897920852 |
| 209773_PM_s_at | RRM2 | ribonucleotide reductase regulatory subunit M2 | 0.967267674 | 0.516531643 |
| 213060_PM_s_at | CHI3L2 | chitinase 3 like 2 | 0.653342435 | 0.364803907 |
| 218350_PM_s_at | GMNN | geminin DNA replication inhibitor | 0.600891795 | 0.192253388 |
| 217714_PM_x_at | STMN1 | stathmin 1 | 0.598102762 | 0.262734907 |
| 200878_PM_at | EPAS1 | endothelial PAS domain protein 1 | 0.588503631 | 0.48338859 |
| 1554696_PM_s_at | TYMS | thymidylate synthase | 0.558038596 | 0.372408001 |
| 202016_PM_at | MEST | mesoderm specific transcript | 0.543696437 | 0.259936021 |
| 227530_PM_at | AKAP12 | A‐kinase anchoring protein 12 | 0.511682439 | 0.405332578 |
| 210358_PM_x_at | GATA2 | GATA binding protein 2 | 0.511546109 | 0.477037794 |
| 219859_PM_at | CLEC4E | C‐type lectin domain family 4 member E | 0.398082121 | 0.207993257 |
| 218782_PM_s_at | ATAD2 | ATPase family AAA domain containing 2 | 0.389173008 | 0.191528324 |
| 206486_PM_at | LAG3 | lymphocyte activating 3 | 0.312979113 | 0.149092455 |
| 238281_PM_at | unidentified | n/a | −0.323326791 | −0.253762725 |
| 212478_PM_at | RMND5A | required for meiotic nuclear division 5 homolog A | −0.333262502 | −0.35407151 |
| 234431_PM_at | GSN | gelsolin | −0.36530257 | −0.112941939 |
| 240765_PM_at | unidentified | n/a | −0.447735132 | −0.29436907 |
| 236409_PM_at | unidentified | n/a | −0.44992291 | −0.249331692 |
| 233263_PM_at | unidentified | n/a | −0.509725068 | −0.312740615 |
| 237376_PM_at | unidentified | n/a | −0.525639819 | −0.250703138 |
| 231034_PM_s_at | NHSL1 | NHS like 1 | −0.534151178 | −0.227014882 |
| 1557685_PM_at | ASAP1‐IT2 | ASAP1 intronic transcript 2 | −0.563114239 | −0.004750863 |
| 232229_PM_at | SETX | senataxin | −0.593424521 | −0.172365985 |
| 241391_PM_at | unidentified | n/a | −0.611242782 | −0.242805807 |
| 236216_PM_at | unidentified | n/a | −0.635686036 | 0.013480067 |
| 244578_PM_at | LCP2 | lymphocyte cytosolic protein 2 | −0.651164906 | −0.257749646 |
| 242854_PM_x_at | DLEU2 | deleted in lymphocytic leukemia 2 | −0.654282894 | −0.274431034 |
| 242800_PM_at | NHS | NHS actin remodeling regulator | −0.668760971 | −0.055646547 |
| 243874_PM_at | unidentified | n/a | −0.720702961 | −0.167061836 |
| 233957_PM_at | unidentified | n/a | −0.725537325 | −0.240100487 |
| 238446_PM_at | NAIP | NLR family apoptosis inhibitory protein | −0.756993933 | −0.460497962 |
| 1560552_PM_a_at | unidentified | n/a | −0.819147799 | −0.391574931 |
| 243954_PM_at | LINC00877 | long intergenic nonprotein coding RNA 877 | −0.880361117 | −0.095247824 |
| 233700_PM_at | PPP1R12B | protein phosphatase 1 regulatory subunit 12B | −0.905378045 | −0.25976984 |
| 221874_PM_at | KIAA1324 | KIAA1324 | −1.001702606 | −0.692655875 |
| (B) Ingenuity Pathway (Tox) analysis | ||
|---|---|---|
| Pathway category | P value | Gene symbols |
| Liver Hyperplasia/Hyperproliferation | 8.75E‐05‐3.8E‐01 | SETX,NHSL1,RRM2,XIST,LCP2,TYMS,C4BPA,ATAD2,LAG3,KIAA1324 |
| Hepatocellular carcinoma | 8.6E‐04‐4.46E‐02 | RRM2,XIST,TYMS,ATAD2 |
| Cardiac inflammation | 1.09E‐03‐1.09E‐03 | TYMS |
| Glomerular injury | 4.34E‐03‐4.34E‐03 | STMN1 |
| Polycythemia | 4.34E‐03‐4.34E‐03 | EPAS1 |
| Renal fibrosis | 4.34E‐03‐4.34E‐03 | STMN1 |
| Kidney failure | 7.58E‐03‐7.58E‐03 | STMN1 |
| Renal proliferation | 7.58E‐03‐7.58E‐03 | STMN1 |
| Liver steatosis | 8.66E‐03‐8.66E‐03 | EPAS1 |
| Anemia | 1.08E‐02‐1.08E‐02 | EPAS1 |
| Renal inflammation | 1.19E‐02‐9.53E‐02 | TYMS,EPAS1 |
| Renal nephritis | 1.19E‐02‐9.53E‐02 | TYMS,EPAS1 |
| Hyperbilirubinemia | 1.83E‐02‐1.83E‐02 | EPAS1 |
| Cardiac enlargement | 3E‐02‐1.85E‐01 | AKAP12,GSN,EPAS1 |
| Pulmonary hypertension | 3.21E‐02‐3.21E‐02 | EPAS1 |
| Renal necrosis/cell death | 4.36E‐02‐2.84E‐01 | GSN,STMN1 |
| Cardiac arrhythmia | 8.44E‐02‐8.44E‐02 | LCP2 |
| Tachycardia | 8.44E‐02‐8.44E‐02 | LCP2 |
| Liver inflammation/hepatitis | 8.8E‐02‐8.8E‐02 | LCP2,AKAP12 |
| Renal damage | 9.14E‐02‐9.14E‐02 | LCP2 |
| Liver necrosis/cell death | 1.63E‐01‐1.63E‐01 | GSN |
| Cardiac necrosis/cell death | 2.25E‐01‐2.25E‐01 | GSN |
Abbreviations: ADNR, acute dysfunction no rejection; AR, acute rejection