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. 2020 May 15;34(9):1957–1971. doi: 10.1111/jdv.16339

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© 2020 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Risk variants identified in various genes involved in EN pathogenesis. Genetic associations have been shown in genes involved in drug metabolism influencing the levels of the drug or its metabolite involved (CYP2B6, CYP2C9, GSTM1); in cellular uptake and peptide presentation by antigen‐presenting cells (ABC transporters, proteasome); in the HLA‐TCR interaction (HLA I, TCR repertoire); in factors influencing CD8 + T‐cell function (CTLA4); in other immune cells shaping the subsequent immune response (HLA II, IL4R, IL13, EP3, TLR3, IKZF1, TRAF3IP2, FasL).