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. 2019 Mar 20;598(14):2847–2873. doi: 10.1113/JP277618

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© 2019 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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SK current in Sham rat VMs with application of ISO

A, representative superimposed traces of I _SK (blue), I _Ca (black) and [Ca²⁺]_i transient (red) recorded in Sham VMs depolarized to −20 mV (left). I _SK was obtained by application of 1 nmol L^–1 APA. Pooled I–V and peak [Ca²⁺]/V relationships. B, representative inward current traces recorded in Sham VMs at 3, 6 and 8 min following application of 100 nmol L^–1 ISO at −10 mV (HP −40 mV). Right: plot of normalized inward current amplitude vs. time after application of ISO. Mean ± SD, n = 5, N = 2. The normalized inward current after 6 min of ISO and 3 min of 100 nmol L^–1 apamin is plotted in red. Mean ± SD, n = 8, N = 7, ^* P = 0.04 vs. ISO only, Student's t test.