Table 3.

Plasma Pharmacokinetic Parameters of Atogepant (Day 10 of Period 2) ^a

Pharmacokinetic Parameter	Atogepant 60 mg Alone b
AUC0‐24h, c μmol·h/L, mean (SD)	7.92 (3.19)
Cmax, nmol/L, mean (SD)	1930 (632)
tmax, h, median (min, max)	1.5 (0.68, 2.02)

AUC_0‐24h, area under plasma drug concentration‐time curve from time 0 to 24 hours; C_max, maximum plasma drug concentration; max, maximum; min, minimum; t_last, time of last measurement; t_max, time when C_max is reached.

^aThree participants had missing values because of early discontinuation from study.

^bMultiple oral doses of atogepant 60 mg (6 × 10‐mg tablets) once daily for 17 consecutive days, starting on day 1 of period 2.

^cAUC_0‐last was used as a close approximation to AUC_0‐24 (t_last range, 23.92 to 23.98 hours).