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. 2020 Sep 3;11:2119. doi: 10.3389/fmicb.2020.02119

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Copyright © 2020 Ahn, Hull, Desai, Rice and Culp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Colonization of the oral cavity and mandibular molars of mice by wild type S. mutans UA159 (WT), ΔlrgAB (lrgAB-deficient) and SAB161 (lrgAB-overexpressing) strains with S. gordonii DL1. (A) Timeline of key events in the experiment (see section “Materials and Methods” for details). (B) Colonization results for each indicated inoculated strain and mouse oral commensals (Commensals) from oral swabs 1–4 and from sonicates of mandibular molars taken at experimental days indicated in the timeline. Results are mean ± SE (n = 20 mice per group) of recovered genomes estimated by qPCR. Statistical comparisons by one-way ANOVA with Tukey-Kramer multiple comparisons test. *p ≤ 0.05 versus the previous swab or an earlier swab as indicated by the swab number, or versus the same point in either the mock (M) or wild type (W) group.