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. 2020 Apr 23;72(1):213–229. doi: 10.1002/hep.31002

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© 2019 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The MVID‐associated myoVb‐P660L mutation causes the intracellular accumulation of canalicular proteins. (A,B) Immunofluorescent microscopy images of myc‐tagged myoVb proteins, ABCC2 and ANO6, in HepG2^KO expressing myc‐myoVb and myc‐myoVb‐P660L. HepG2^KO cells expressing myoVb‐P660L show intracellular colocalization of myc and ABCC2 (white arrows). Yellow arrowheads indicate BCs. Scale bars: 10 μm. (C) Quantification of the percentage of myc‐positive cells that show intracellular clusters/accumulations of myc localized with ANO6. (D) Quantification of the percentage of myc‐positive cells that show subapical localization of myc‐tagged myoVb proteins.