TABLE 2.
Evogliptin | Linagliptin | Difference [95% CI] or P‐value | |
---|---|---|---|
(n = 100) | (n = 104) | ||
HbA1c (%) | |||
Baseline | |||
Mean ± SD | 7.55 ± 0.78 | 7.63 ± 0.78 | |
At week 12 | |||
Mean ± SD | 6.70 ± 0.73 | 6.88 ± 0.91 | |
Change from baseline to week 12 (mean ± SD) | −0.85 ± 0.67 | −0.75 ± 0.87 | −0.10 [−0.32, 0.11] |
P‐value for mean difference from baseline at week 12 | <.0001 a | <.0001 a | |
HbA1c response rate | n (%) | n (%) | |
<7.0% | 68 (68.0) | 7 0(67.3) | 1.0000 c |
≥7.0% | 32 (32.0) | 34 (32.7) | |
<6.5% | 44 (44.0) | 38 (36.5) | .3182 c |
≥6.5% | 56 (56.0) | 66 (63.5) | |
Fasting plasma glucose (mg/mL) | |||
Baseline | |||
Mean ± SD | 144.1 ± 24.7 | 151.1 ± 26.9 | |
At week 12 | |||
Mean ± SD | 131.3 ± 23.0 | 135.7 ± 33.5 | |
Change from baseline to week 12 (mean ± SD) | −12.8 ± 19.5 | −15.4 ± 34.1 | .3253 d |
P‐value for mean difference from baseline at week 12 | <.0001 b | <.0001 a |
Abbreviations: CI, confidence interval, SD, standard deviation.
P‐values were derived from a Wilcoxon signed‐rank test.
P‐values were derived from a paired t‐test.
P‐values were derived from a Fisher's exact test.
P‐values were derived from a Wilcoxon rank‐sum test.