Table 1.
IGHV and IGKV sequences of 10 salivary gland mucosa‐associated lymphoid tissue–type lymphomas of Sjögren’s syndrome patients
| Patient | Ig isotypea | IGHV; IGKV rearrangements | IGHV; IGKV somatic mutationsb | VH‐CDR3; VK‐CDR3 sequencec | VH‐CDR3; VK‐CDR3 length§ | IgM produced |
|---|---|---|---|---|---|---|
| M83 | IgM | V3‐74/D4‐23/JH4; VK1‐39/JK1 | 22; 9 | C AREYGNSRFFDY WGQG; C QQSYTSPRT FGQG | 12; 9 | No |
| M86 | IgM | V3‐30/D6‐13/JH4; VK3‐15/JK1 | 21; 11 | C AQGAFSNKWYSIGDY WGQG; C QQYNNWPPWT FGQG | 15; 10 | Yes |
| M87 | IgM | V1‐2/D5‐18/JH5 | 17 | C ARGQGTQVSHSWFDP WGQG | 15 | No |
| M88 | IgM | V1‐69/D5‐12/JH4 | 21 | C AREGKASVANGAFDY WGQG | 15 | No |
| M89 | IgM | V4‐59/D6‐6/JH3; VK3‐15/JK1 | 5; 5/7 | C ARDIANIATRRDDAFDI WGQG; C QHYNNWPPWT FGQG | 17; 10 | Yes |
| M91 | IgM | V1‐69/D5‐24/JH4; VK3‐20/JK2 | 7; 0 | C ARKGGDRGDAYDVFDY WGQG; C QQYGSSPYT FGQG | 16; 9 | Yes |
| M93‐I | IgM | V3‐7/D3‐22/JH3; VK3‐15/JK1 | 6/9; 5 | C ARGDYYDSGGS(S/N)YHDAFDV WGQG; C QHYNNWPPWT FGQG | 19; 10 | Yes |
| M93‐II | IgM | V4‐59/D3‐10/JH5; VK4‐1/JK2 | 12; 11 | C ACGGGGSGTYFRGWFDP WGQG; C QQYYSTLYT FGQG | 17; 9 | No |
| M94 | IgM | V3‐7/D3‐22/JH3; VK3‐15/JK1 | 10; 5 | C ARGDYYDSSGYYIDAFDI WGQG; C QHYNNWPPWT FGQG | 18; 10 | Yes |
| M95 | IgM | V3‐48/D3‐22/JH3; VK3‐15/JK4 | 18; 12 | C AREPYSDSSSFFPGSFDI WGQG; C QQYDNWPLT FGGG | 18; 9 | No |
| M96 | IgM | V3‐30.3/D2‐8/JH3; VK3D‐15/JK1 | 23/24; 4 | C ARAGQGSNGIW(G/D)GAFD(T/S) WGQG; C QHYNNWPPWT FGQG | 17; 10 | Yes |
a
Determined by reverse transcription–polymerase chain reaction.
b
Values are the number of mutations. Two values separated by a slash sign signify identification of molecular IGHV/IGKV clones harboring slightly different numbers of somatic mutations.
c
For the VH– and VK–third complementarity‐determining region (CDR3) sequences in which 2 amino acids separated by a slash sign are depicted, this indicates that 2 molecular IGHV clones with dissimilar amino acids at this position were identified.
d
Values are the number of amino acids.