Table 1.
IC50 values of the compounds 4, 6, 9 and 10 by TLR2/1 stimulation (Pam3CSK4, 10 ng/mL) and TLR2/6 stimulation (Pam2CSK4, 1 ng/mL) in HEK‐Blue hTLR2 cells (n=3).
|
Compound |
TLR2/1 IC50 [μM][a] |
TLR2/6 IC50 [μM][a] |
|---|---|---|
|
4 |
44.9 (28.1–72.0) |
61.9 (18.7–204.6) |
|
6 |
15.4 (8.9–26.4) |
13.6 (9.9–18.6) |
|
9 |
42.4 (36.9–48.7) |
42.9 (36.9–49.9) |
|
10 |
44.0 (33.8–57.4) |
40.7 (30.9–53.6) |
[a] 95 % confidence interval shown in brackets.