Table 1.
EC50 values for DHA (2), artesunic acid (3), afimoxifene (4‐OHT, 7), precursor 57 and hybrids 10–29 against human prostate (PC‐3) and breast cancer (MCF‐7) cell lines.
|
Compound |
MW [g/mol] |
PC‐3 |
MCF‐7 |
||
|---|---|---|---|---|---|
|
EC50 [μM] |
SD |
EC50 [μM] |
SD |
||
|
afimoxifene (7) |
387.52 |
75.1 |
81.5 |
19.3 |
17.5 |
|
DHA (2) |
284.35 |
263 |
82.5 |
49.3 |
6.33 |
|
artesunic acid (3) |
384.43 |
195 |
72.4 |
32.0 |
5.67 |
|
10 |
753.93 |
45.6 |
4.29 |
20.0 |
1.65 |
|
11 |
695.90 |
16.0 |
4.58 |
15.7 |
4.95 |
|
12 |
723.90 |
6.38 |
8.90 |
22.1 |
57.1 |
|
13 |
665.87 |
2.74 |
2.17 |
3.91 |
4.15 |
|
14 |
636.78 |
14.3 |
4.01 |
27.7 |
7.54 |
|
15 |
636.78 |
20.7 |
19.3 |
>1000 |
– |
|
16 |
650.81 |
41.8 |
119 |
14.8 |
3.75 |
|
17 |
654.77 |
179 |
176 |
17.4 |
5.22 |
|
18 |
638.75 |
10.5 |
14.4 |
51.8 |
44.6 |
|
19 |
680.79 |
114 |
31.6 |
23.8 |
5.04 |
|
20 |
650.81 |
111 |
70.2 |
56.7 |
61.2 |
|
21 |
664.84 |
14.1 |
10.0 |
7.03 |
4.19 |
|
22 |
678.86 |
5.62 |
0.82 |
5.23 |
3.76 |
|
23 |
717.87 |
3.23 |
1.72 |
2.08 |
0.45 |
|
24 |
717.87 |
2.04 |
0.61 |
3.09 |
0.85 |
|
25 |
659.84 |
3.76 |
0.85 |
2.84 |
1.52 |
|
26 |
1084.28 |
33.7 |
1.72 |
22.3 |
3.48 |
|
57 |
351.46 |
>1000 |
– |
165 |
50.6 |
|
57+3 (1 : 1) |
351.46+384.43 |
156 |
45.4 |
33.7 |
6.03 |
|
27 |
755.92 |
1.18 |
1.44 |
52.7 |
154 |
|
28 |
755.92 |
1.07 |
0.18 |
>1000 |
– |
|
29 |
747.90 |
3.94 |
1.44 |
3.86 |
1.85 |