Table 1.
Pharmacokinetic parameters (mean ± SD) of voriconazole in plasma and tear fluid samples
| Parameters | Plasma | Tear fluid |
|---|---|---|
| C max (μg/mL) | 3.29 ± 0.10 | 1.85 ± 0.26 |
| T max (h) | 1.45 ± 0.37 | 1.60 ± 0.55 |
| t 1/2α (h) | 0.25 ± 0.08 | NA |
| t 1/2β (h) | 16.4 ± 4.37 | 25.2 ± 9.19 |
| AUC0–24 (μg∙h/mL) | 44.0 ± 3.89 | 36.8 ± 4.54 |
| AUC0–inf (μg∙h/mL) | 73.3 ± 19.6 | 74.8 ± 17.0 |
| AUMC (μg∙h2/mL) | 1916 ± 1074 | 2868 ± 1827 |
| MRT (h) | 24.7 ± 6.75 | 36.2 ± 13.3 |
C max and T max, maximum concentration and time to C max, respectively; t 1/2α and t 1/2β, absorption and elimination half‐lives, respectively; AUC (AUC0‐24 and AUC0‐inf), area under the concentration vs time curve (AUC from time 0 to 24 h and AUC from time 0 h to infinity, respectively).
Abbreviations: AUMC, area under the first moment curve from time 0 to infinity; MRT, mean residence time; NA, not applicable.