Table 1.
Patient characteristics (n = 178)
CPLN negative | CPLN positive (≥5 mm) | P value a | |||
---|---|---|---|---|---|
Median | IQR | Median | IQR | ||
Age (y) | 64.70 | 50.15‐73.54 | 63.48 | 51.42‐71.42 | .872 |
FIGO stage | |||||
IIIA/IIIB | 16 | 18.0 | 2 | 2.2 | |
IIIC | 62 | 69.7 | 11 | 12.4 | |
IVA | 11 | 12.3 | 2 | 2.2 | |
IVB | 0 | 0 | 74 | 83.2 | .0001 |
Histologic subtype | |||||
High‐grade serous | 69 | 77.5 | 73 | 82.0 | |
Low‐grade serous | 12 | 13.5 | 3 | 3.4 | |
Mucinous | 1 | 1.1 | 2 | 2.2 | |
Endometrioid | 5 | 5.6 | 8 | 9.0 | |
Clear cell | 2 | 2.3 | 3 | 3.4 | .205 |
Grading | |||||
G1 | 13 | 14.7 | 4 | 4.5 | |
G2 | 43 | 48.3 | 39 | 43.8 | |
G3 | 33 | 37.0 | 46 | 51.7 | .029 |
Debulking surgery | |||||
Yes | 89 | 100 | 89 | 100 | |
No | 0 | 0 | 0 | 0 | |
Residual disease | |||||
No residual disease | 80 | 89.9 | 53 | 59.6 | |
Residual disease | 9 | 10.1 | 36 | 40.4 | .0001 |
Lymphadenectomy b | |||||
Systematic (≥20 nodes) | 79 | 88.8 | 71 | 79.8 | |
Sampling (<20 nodes) | 2 | 2.2 | 6 | 6.7 | .199 |
Adjuvant chemotherapy | |||||
Carboplatin + paclitaxel | 77 | 86.5 | 73 | 82.0 | |
Carboplatin | 11 | 12.4 | 13 | 14.6 | |
Cisplatin + endoxan | 1 | 1.1 | 3 | 3.4 | .529 |
Platinum response c | |||||
Refractory + resistant | 14 | 15.7 | 21 | 23.6 | |
Sensitive | 75 | 84.3 | 68 | 76.4 | .403 |
Recurrence | |||||
Yes | 42 | 47.2 | 77 | 86.5 | |
No | 47 | 52.8 | 12 | 13.5 | .0001 |
Death | |||||
Yes | 27 | 30.3 | 53 | 59.6 | |
No | 62 | 69.7 | 36 | 40.4 | .0001 |
Values are expressed as median, IQR for ‘Age’ and as n, % for all other characteristics.
Abbreviations: CPLN, cardiophrenic lymph node; FIGO, Fédération Internationale de Gynécologie Obstétrique; IQR, interquartile range.
Differences assessed by Mann‐Whitney U test (Age) or chi‐square test.
Systematic retroperitoneal lymphadenectomy. 12
Platinum sensitivity according to The Fifth Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup: recurrent disease. 13