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Schematic representation of the DNA origami nanostructure (left). Each of the 5 “wells” in the origami tile carries two biotinylated staples for the attachment of streptavidin and, subsequently, biotinylated lysozyme (right). Fourteen aptamers, hybridized with staples at the four sides of the DNA origami, drive the attachment of the nanostructures to the bacterial targets. Four Alexa 647 molecules act as detection beacons for the nanostructure.
