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. 2020 Apr 30;59(31):12837–12841. doi: 10.1002/anie.202000148

Figure 3.

Figure 3

LL‐37 binding to IAPP fibrils (fIAPP) converts them into seeding‐incompetent assemblies: a) Fibrillogenesis of IAPP (16.5 μm) alone or following seeding with 10 % fIAPP or with 10 % LL‐37‐treated fIAPP determined by ThT binding (means±SD, 3 assays). b) TEM images of solutions from (a): fIAPP seeds, LL‐37‐treated fIAPP seeds, and IAPP seeded with fIAPP (10 %, red dot) or LL‐37‐treated fIAPP (10 %, blue dot; both at 6 h). Scale bars=100 nm.