Table 3.
Risk factors for venous thromboembolism
| VTE (N = 39) | No VTE (N = 159) | Univariable SHR (95% CI)c | Multivariable SHR (95% CI)d | |
|---|---|---|---|---|
| Mean age, years (SD) | 62 (10) | 60 (15) | 0.98 (0.8‐1.2)a | 1.05 (0.82‐1.4)a |
| Male sex | 27 (69) | 103 (65) | 0.7 (0.4‐1.5) | 0.53 (0.27‐1.0) |
| Intensive care unit | 35 (89) | 40 (25) | 7.9 (2.8‐23) | 8.9 (3.2‐25) |
| Median body weight, kg/m2 (IQR) | 82 (74, 93) | 84 (75, 95) | 0.6 (0.2, 2.3)b | 0.9 (0.2, 3.9)b |
| History of venous thromboembolism | 3 (7.9) | 8 (5.2) | 1.1 (0.3‐3.0) | 1.6 (0.4‐7.2) |
| Anticoagulant use at admission | 0 (0) | 19 (12) | ||
| Mean hemoglobin, mmol/L (SD) | 8.0 (1.4) | 7.9 (1.2) | 1.04 (0.8‐1.4)b | 1.1 (0.8‐1.5)b |
| Median white blood cell count, ×109/L (IQR) | 7.6 (5.9, 11) | 6.9 (5.4, 9.3) | 1.9 (1.1, 3.2) | 1.9 (0.9, 4.1)b |
| Median neutrophil count, ×109/L | 6.0 (4.4‐8.1) | 5.2 (3.8‐7.1) | 2.0 (0.99‐4.0) | 1.7 (0.8‐3.7)b |
| Median lymphocyte count, ×109/L | 0.59 (0.47‐0.83) | 1.0 (0.8‐1.3) | 0.66 (0.43‐1.02) | 0.7 (0.4‐0.95)b |
| Median neutrophil‐to‐lymphocyte ratio | 11 (7.0‐15) | 5.4(3.5‐8.1) | 2.0 (1.3‐3.1)b | 1.7 (1.2‐2.5)b |
| Mean platelet count, ×109/L | 246 (87) | 237 (95) | 1.02 (0.99‐1.1)a | 1.002 (0.97‐1.04)a |
| Median D‐dimer, mg/L (IQR) | 2.6 (1.1, 18) | 1.0 (0.7, 1.7) | 1.6 (1.2, 2.1)b | 1.4 (1.1, 1.9) |
Abbreviations: IQR, interquartile range; SD, standard deviation; SHR, subdistribution hazard ratio; VTE, venous thromboembolism.
a
Per 10‐unit increase.
b
Per 1‐unit increase.
c
Variables with a non‐normal distribution (ie, body weight, white blood cell count, neutrophil count, lymphocyte count, neutrophil‐to‐lymphocyte ratio, and D‐dimer) were analyzed log‐transformed.
d
Multivariable analysis were adjusted for age, sex, and intensive care unit admission.