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. 2020 Oct;27(10):418–422. doi: 10.1101/lm.051714.120

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Published by Cold Spring Harbor Laboratory Press

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Figure 3. — Optogenetic silencing of DLS disrupts early reversal. (A) DLS photosilencing during touchscreen reversal learning. (B) DLS-silencing did not affect the number of sessions to attain reversal criterion (unpaired Student's t-test: t₍₁₃₎ = 0.94, P > 0.05) or (C) correct responding at any stage of reversal (ANOVA group-effect: F_(1,13) = 1.61, P > 0.05; stage-effect: F_(2,26) = 177.15, P < 0.01; interaction: F_(2,26) = 0.42, P > 0.05). (D) Silencing did, however, increase the number of total errors made, specifically at ^ER (ANOVA group-effect: F_(1,13) = 0.76, P > 0.05; stage-effect: F_(2,26) = 134.83, P < 0.01; interaction: F_(2,26) = 8.71, P < 0.01). (E) This effect was largely driven more perseverative errors (ANOVA group-effect: F_(1,13) = 1.03, P > 0.05; stage-effect: F_(2,26) = 203.78, P < 0.01; interaction: F_(2,26) = 9.93, P < 0.01), (F) though nonperseverative errors were also visibly higher (ANOVA group-effect: F_(1,13) = 0.32, P > 0.05; stage-effect: F_(2,26) = 14.24, P < 0.01; interaction: F_(2,26) = 3.39, P < 0.05). n = 7–8 per group. Data are means ± SEM. (*) P < 0.05.