Table 2.
Number of SNPs included in instrument, estimate of the proportion of variance in risk factor explained by the instrument (R 2) and F‐statistic for each instrument, across all adipokines and CRP
| Risk factor | Number of SNPs in instrument | R 2 | F‐statistic |
|---|---|---|---|
| Adiponectin | 8 | 0.016 | 60.8 |
| CRP | 45 | 0.035 | 119.4 |
| HGF | 1 | 0.012 | 40.1 |
| IL‐6 | 3 | 0.002 | 51.4 |
| Leptin receptor | 1 | 0.54 | 3,872.7 |
| PAI‐1 | 3 | 0.0064 | 65.5 |
| Resistin | 1 | 0.030 | 103.3 |
Abbreviations: CRP, C‐reactive protein; HGF, hepatocyte growth factor; IL‐6, interleukin‐6; PAI‐1, plasminogen activator inhibitor‐1; SNPs, single‐nucleotide polymorphisms.
R 2 indicates proportion of variance in risk factor explained by genetic instrument.