Figure 3.

Growing and non‐growing hair pool on oral drug treatment during and after topical lotions. In order to illustrate changes on combined treatment, we calculated absolute values at tx (m1, m2, m3 or m6) relative to baseline values (m0; considered as 100%; Colour figure can be viewed at wileyonlinelibrary.com). The two panels show growing (left; average anagen) and non‐growing (right; average catagen‐telogen) hair with a diameter ≥30 µm. The combined drug group with 5% minoxidil lotion (plain bars) reflects increased average growth as compared with the combined drug group applying control lotion (empty bars). The hatched bar appearing on top reflects standard deviation. Interestingly, the variations in anagen/telogen occur specifically during treatment or after the weaning of topical MTS 5% with no evidence that the duration of telogen would be significantly affected. Indeed, there was no change in catagen‐telogen fraction (m1, m2 and m3 in the panel on the right) until after withdrawal of topical minoxidil with completion of the catagen‐telogen phase (m6). This indicates that the regression wave from growth to rest will not be prevented by oral intake of finasteride alone, that it represents a “rebound” phenomenon and that it will turn soon in a major hair shedding phase after the 3rd month post‐MTS 5%[Colour figure can be viewed at wileyonlinelibrary.com]