Table 2.

The data in first two columns show units applicable to a range of hair parameters like in Table 1, and the 3rd column separates the two treatment groups (minoxidil 5% topical solution; MTS (n = 7) vs control lotion (n = 15)). Table displays first thinnest hair data (nano‐hair <20 µm) followed by thicker hair data separated into anagen (bold) and telogen (italic) and finally shedding or exogen hair and lastly growth rates (LHGR) of thinner and thicker hair fibres

Units	Parameter	Group topical	No‐treatment		On‐topical						Off‐topical 3 mo
			Baseline (m0)		Change from baseline m0						Change from m0		Change from m3
					m1		m2		m3		m6 vs m0		m6 vs m3
			Mean	SD		P		P		P		P		P
n/cm2	Nano‐hair <20 µm	MTS	34.7	26	−2.2		−5.1		−8.4		−18.6	*	−10.1
		Control	23.9	6.1	3.4		−3.6		4		2		−1.9
n/cm2	Anagen ≥20 µm	MTS	128.8	65	−1.9		57.5	*	81.2	***	−29.6		−110.8	***
		Control	96.7	44.7	0.8		11		5.5		−4		−9.5
	Telogen ≥20 µm	MTS	104.5	36.3	−6.6		−15.2		−33.2	*	47.7	*	80.9	***
		Control	108.1	52.1	−9.8		−0.4		−5.2		7.4		12.6
n/cm2	Anagen ≥30 µm	MTS	108.5	61.9	0		46.4	*	68.5	**	−22.5		−91	***
		Control	79.8	44.8	3.4		4.8		6.5		−3.8		−10.2
	Telogen ≥30 µm	MTS	67.4	40	2.7		−10.3		−14.4		53.1	*	67.5	*
		Control	41.7	13.8	1		4.1		2.4		9.9		7.5
n/cm2	Anagen ≥40 µm	MTS	82.4	57	−1.7		36.6	*	57.7	**	−12.6		−70.3	***
		Control	69.2	48	1.3		2.2		1.9		−2.3		−4.3
	Telogen ≥40 µm	MTS	34.8	19.9	−2		−5.1		−5	*	40.9	*	45.8	**
		Control	20.4	10.9	−2.4		1.2		4.5		4.4		0
n/cm2	Anagen ≥50 µm	MTS	68	50.6	−0.9		26.9		44.2	**	−8.7		−52.8	**
		Control	60.8	49.3	2.9		3.3		1.5		−1.9		−3.4
	Telogen ≥50 µm	MTS	21.3	10.9	−0.2		−2.4		‐5	*	26.6	*	31.6	**
		Control	12.8	10.6	−1.3		−1.3		4		1.4		−2.6
n/cm2	Exogen	MTS	10.143	5.24	6.57		15	*	−0.29		2.29		2.57
		Control	11.53	8.77	2		1.99		2.19		1.72		−0.47
LHGR	Hair diameter (D; µm)
µm/24 h	30 µm ≤ D < 60 µm	MTS	256.2	53.3	−13.9		−11.7		19.1		2.2		−16.9
		Control	267.5	41.5	−20.5		−7.8		7.6		−34.9		−42.5
µm/24 h	D ≥ 60 µm	MTS	369	39.2	−56.3		−45.1		−64.5		−50.9		13.5
		Control	351.7	64.9	−20.4		7.7		14.1		−33.9		−48.1

Descriptive statistics of absolute values (mean and SD) are shown at baseline before drug administration (m0) and there were no statistically significant differences between MTS and control lotion groups at baseline. Changes from baseline recorded during the 3 mo of combined drug administration (oral finasteride during “on‐topical” period; m1, m2 and m3) are shown each month and are followed by a display of P values *≤.05, **≤.005, ***≤.0005. The last columns show changes during maintenance of oral drug intake after weaning of topicals (“off‐topical” 3 mo) as compared either to baseline (change from m0; m6 vs m0) or to the last topical applications (change from m3; m6 vs m3), and each time point is followed by the P values. At m3 in the group applying the topical lotion containing MTS5%, there were significant increases in anagen hair in all classes of diameter and decreases in all telogen hair counts (except those grouping diameters ≥30 µm) indicating recruitment of scalp hair follicles into the growth phase. Of note is that all absolute anagen increases exceeded absolute telogen decreases suggesting recruitment of dormant‐empty hair follicles. The collection of exogen hair raised as from m1 but statistically significantly peaked at m2. There was no modification in LHGR. After weaning of topicals but maintenance of oral drug intake, all telogen counts significantly increased as compared to baseline (m6 vs m0), while all anagen counts dropped and all telogen increased at m6 in comparison with m3 (m6 vs m3). The “post‐minoxidil rebound” is reflected by increased resting hair (m6 vs m3 and m6 vs m0). Oral drug with control lotion did not statistically significantly fluctuate during the 6‐mo follow‐up.