Table 2.

Brain magnetic resonance imaging (MRI) data from retrospective analyses

Patient	Age at MRI	Time to MRI†	MRI findings on retrospective analysis
			Cerebellar atrophy	Brain‐stem atrophy	Ventriculo‐megaly	Hippocampal internal structure	Corpus callosum thinning	White matter changes	Thalamic T2 hypointensity	Cerebral atrophy
1	3 years, 7 months	3 months	++ S > I	Yes Pons most affected	+	Normal	Normal	++ P > A	Normal	+
2	3 years, 1 month	7 months	+++	Yes	++	Reduced internal architecture	+ P > A	++ P > A	+	++, +++ P > A
4	5 years, 7 months	2 years, 7 months	++ S > I	Yes	++	Normal	Normal	+	+	++ P > A
5	3 years, 9 months	3 months	++ S > I	Yes	++	Reduced internal architecture	Normal	++	Normal	Normal
6	3 years, 4 months	8 months	+ S > I	Yes Pons	+/++	Normal	Normal	+	+	Normal
8	3 years, 3 months	1 month	++/+++	Yes Pons	+	Reduced internal architecture	+	+	Normal	+/++ P > A
9	3 years, 5 months	5 months	+++	Yes Pons most affected	+/++	Reduced internal architecture	+	+	+	++/+++ P > A
10	4 years, 9 months	1 year, 3 months	+ S > I	Yes Pons	++	Reduced internal architecture	+	+	+	++ P > A
11	1 year, 10 months	NA‡	Normal	No	+	Reduced internal architecture	+	+	Normal	+ P > A
	3 years, 3 months	NA‡	++ S > I	No	+/++	Reduced internal architecture	+	++	Normal	++ P > A
13	3 years, 4 months	5 months	Normal	Yes Pons	+	Reduced internal architecture	Normal	+ P > A	Normal	Normal
	4 years, 7 months	1 year, 8 months	+ Vermis	Yes Pons	+	Reduced internal architecture	+ P > A	+/++ P > A	Normal	++ P > A

^† Time to MRI is time from initial seizure to MRI being performed.

^‡ Patient diagnosed before symptom presentation.

+, mild; ++, moderate; +++, severe; NA, not applicable; P > A, posterior more than anterior; S > I, superior more than inferior.