TABLE 1.
Patient and Control Demographics and Baseline Characteristics
| Variables | PD N = 416 | HCs N = 192 | P | |
|---|---|---|---|---|
| DEMOGRAPHIC | Age, yr | 61.7 (9.6) | 60.8 (11.3) | 0.3 |
| Sex |
M = 272 (65.4%) F = 144 (34.6%) |
M = 123 (64.0%) F = 69 (35.9%) |
0.8 | |
| Education, yr | 15.5 (3.0) | 16.0 (2.9) | 0.06 | |
| APOE ε4 status |
0 alleles = 277 (73.3%) 1 allele = 92 (24.3%) 2 alleles = 9 (2.4%) Missing data = 38 |
0 alleles = 129 (73.7%) 1 allele = 42 (24.0%) 2 alleles = 4 (2.3%) Missing data = 17 |
>0.99 | |
| Age at onset, yr | 59.7 (9.9) | NA | — | |
| Disease duration, mo | 6.7 (6.5) | NA | — | |
| MOTOR | UPDRS III tremor |
0.5 (0.3) N = 415 Missing data = 1 |
0.03 (0.08) N = 191 Missing data = 1 |
<0.0001 |
| UPDRS III PIGD |
0.23 (0.22) N = 415 Missing data = 1 |
0.02 (0.09) N = 191 Missing data = 1 |
<0.0001 | |
| COGNITIVE | MoCA |
27.1 (2.3) N = 413 Missing data = 3 |
28.2 (1.1) N = 192 |
<0.0001 |
| HVLT |
10 (−4‐12) N = 414 Missing data = 2 |
11 (−4‐12) N = 192 |
<0.001 | |
| SFT |
48.8 (11.6) N = 415 Missing data = 1 |
51.9 (11.3) N = 192 |
<0.01 | |
| JOLO |
13 (5‐15) N = 415 Missing data = 1 |
14 (4‐15) N = 192 |
0.06 | |
| LNS |
10.6 (2.6) N = 415 Missing data = 1 |
10.9 (2.6) N = 192 |
0.1 | |
Data listed = mean (SD) for normally distributed variables or median (range) for non‐normally distributed variables and frequency (%) for categorical variables. Missing data noted in each cell where applicable. APOE = apolipoprotein E; HCs = healthy controls; HVLT = Hopkins Verbal Learning Test Discrimination Recognition Score; JOLO = Benton judgement of line orientation score; LNS = Letter‐number sequencing score; MoCA = Montreal Cognitive Assessment; PD = Parkinson's disease; PIGD = postural instability and gait disturbance subscore of UPDRS; SFT = semantic fluency total score; Tremor = Tremor subscore of UPDRS; UPDRS = Unified Parkinson's Disease Rating Scale.