TABLE 3.
Baseline CSF Data by APOE Genotype
| CSF analyte | PD | HCs | ||||||
|---|---|---|---|---|---|---|---|---|
| APOE 4 + N = 101 | APOE 4 – N = 277 | Effect size r | p | APOE 4 + N = 46 | APOE 4 – N = 129 | Effect Size r | p | |
| CSF Aβ42 | 697.1 (238.8–1795.0) Missing = 1 | 912.8 (249.0–3707.0) Missing = 4 | 0.26 | <0.0001 | 673.1 (239.1–1890.0) Missing = 1 | 994.8 (336.1–3297.0) Missing = 3 | 0.31 | <0.0001 |
| CSF t‐tau | 152.0 (85.0–349.8) Missing = 5 | 159.9 (80.9–467.0) Missing = 8 | 0.04 | 0.48 | 189.5 (93.3–554.5) Missing = 2 | 168.6 (82.0–580.8) Missing = 2 | 0.04 | 0.57 |
| CSF p‐tau | 13.3 (8.0–28.0) Missing = 12 | 13.6 (8.0–40.1) Missing = 22 | 0.03 | 0.56 | 17.0 (8.2–60.0) Missing = 4 | 15.3 (8.1–73.6) Missing = 10 | 0.05 | 0.52 |
| CSF aSyn | 1256.5 (432.4–3022.3) | 1432.7 (472.0–5256.9) Missing = 2 | 0.13 | 0.01 | 1522.0 (488.6–4683.1) Missing = 1 | 1662.6 (600.7–4271.3) Missing = 1 | 0.07 | 0.36 |
Data listed = median (range). Number of missing data points is noted in each cell. Aβ42 = cerebrospinal fluid amyloid‐beta 1 to 42; aSyn = cerebrospinal fluid total alpha‐synuclein; HCs = healthy controls; PD = Parkinson's disease; p‐tau = cerebrospinal fluid phosphorylated tau at threonine 181; t‐tau = cerebrospinal fluid total tau.