TABLE 4.
Baseline CSF AB Groups
| PD − A | PD + A | HC − A | HC + A | |
|---|---|---|---|---|
| N (% total) | 281 (68.5%) | 129 (31.5%) | 136 (72.3%) | 52 (27.7%) |
| Sex F (%F) | 99 (35.2%) | 41 (31.8%) | 50 (36.8%) | 18 (34.6%) |
| Age at CSF | 61.5 (9.6) | 62.2 (9.6) | 60.7 (10.8) | 61.0 (13.0) |
| Disease duration | 4.2 (0.4–34.8) | 4.6 (0.7–34.7) | NA | NA |
| CSF t‐tau | 169.50 (85.6–467.0) |
124.1 a (80.9–339.2) Missing = 12 |
183.0 (93.7–420.5) |
126.8b (81.96–580.8) Missing = 3 |
| CSF p‐tau |
14.04 (8.2–40.1) Missing = 3 |
Missing = 33 |
15.6 (8.1–39.1) Missing = 1 |
12.8 (8.2‐73.6) Missing = 13 |
| CSF aSyn |
1522.3 (606.1–5256.9) Missing = 1 |
1026.6 a (432.4–3638.3) | 1696.2 (733.8–4271.3) | 1131.9b (488.6–4683.1) |
Data listed = frequency (%) for categorical data, mean (standard deviation) for normally distributed data or median (range) for non‐normally distributed data. Number of missing data points is noted in each cell. aSyn = cerebrospinal fluid total alpha‐synuclein; HC − A = healthy controls with normal CSF Aβ42 levels; HC + A = HC with pathologically low CSF Aβ42 levels; PD − A = Parkinson's disease with normal CSF Aβ42 levels; PD + A = PD with pathologically low CSF Aβ42 levels; p‐tau = cerebrospinal fluid phosphorylated tau at threonine 181; t‐tau = cerebrospinal fluid total tau.
p < 0.0001 PD + A vs PD − A;
p < 0.0001 HC + A vs HC − A;
p < 0.03 PD + A vs HC + A.