TABLE 5.
Mean Estimates of Change in AD CSF Biomarkers in PD and Healthy Controls
| Variable | PD | HCs | ||||||
|---|---|---|---|---|---|---|---|---|
| 6 mo | 1 yr | 2 yr | 3 yr | 6 mo | 1 yr | 2 yr | 3 yr | |
| Aβ42 | ||||||||
| Estimate (SE) | −14.29 (12.88) | −13.01 (13.08) | −35.39 (13.36) a | −42.27 (14.47) a | 27.53 (17.28) | 28.82 (17.37) | 6.44 (17.67) a | −0.44 (18.38) a |
| (95% CI) | (−39.56, 10.97) | (−38.67, 12.65) | (−61.60, −9.18) | (−70.65, −13.88) | (−6.38, 61.45) | (−5.26, 62.89) | (−28.23, 41.10) | (−36.50, 35.62) |
| p‐tau | ||||||||
| Estimate (SE) | −0.14 (0.15) | 0.06 (0.15) | 0.07 (0.15) a | 0.41 (0.16) a | 0.24 (0.20) | 0.44 (0.20) | 0.45 (0.20) a | 0.79 (0.21) a |
| (95% CI) | (−0.43, 0.15) | (−0.23, 0.36) | (−0.23, 0.37) | (0.09, 0.74) | (−0.15, 0.63) | (0.05, 0.83) | (0.05, 0.84) | (0.37, 1.20) |
| t‐tau | ||||||||
| Estimate (SE) | 0.13 (1.81) | 1.67 (1.83) | 1.93 (1.87) a | 4.75 (2.01) a | 3.87 (2.43) | 5.40 (2.44) | 5.66 (2.48) a | 8.49 (2.57) a |
| (95% CI) | (−3.41, 3.68) | (−1.93, 5.26) | (−1.73, 5.59) | (0.81, 8.69) | (−0.90, 8.63) | (0.61, 10.18) | (0.80, 10.53) | (3.45, 13.52) |
Estimates based on the raw values (not the ranks) from models adjusting for age, sex, and baseline CSF outcome value. AIC criteria determined APOE included in Aβ42 model.
a
Denotes p < 0.0001 for within‐group comparison of estimates between time point and 6‐mo reference category.