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. 2020 May 5;39(3):681–709. doi: 10.1007/s10555-020-09883-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Relationships between FOX proteins. Apart from the conventional signalling pathways, FOXO proteins are also regulated by other FOX proteins which modulate FOXO activity. FOXO proteins are the central axis of many signalling pathways which determine cell fates. Downregulation of FOXO proteins enhances cell proliferation, invasion, metastasis and angiogenesis