Table 3. Genotypes of Field Isolated Parasite Strains: Whole Genome Sanger Sequencing Identified Mutations in Three Parasite Genes (CRT, PfMDR1, and PfDHFR) Associated with Drug Resistancea.
| PfCRT | PfMDR1 | PfDHFR | ||||||
|---|---|---|---|---|---|---|---|---|
| sample ID | K76T | N86Y | Y184F | N1042D | N51I | C59R | S108N | I164L |
| GB0006 | X | X | X | N | X | X | N | L |
| GB0004 | K | N | Y | N | N | R | N | L |
| GB0026 | K | N | X | N | N | R | N | L |
| GB002 | T | N | X | N | I | C | N | L |
| GB0021 | K | N | F | N | X | X | N | L |
| GB0048 | X | N | F | N | I | C | N | L |
| GB0071 | X | N | Y | N | N | C | N | L |
| GB0087 | T | N | Y | N | I | C | N | L |
| GB0020 | T | Y | Y | N | I | C | N | L |
a
Shown are the amino acid changes associated with each of these three genes and whether the parasite strain contained the mutation.