Table 2. Direct Comparison between Inhibition Constant (Ki) and IC50 Values for 3b and 3e.
|
3b |
3e |
|||||||
|---|---|---|---|---|---|---|---|---|
| [3H]naloxone |
[3H]DAMGO |
[3H]naloxone |
[3H]DAMGO |
|||||
| region | IC50/nM | Ki/nM | IC50/nM | Ki/nM | IC50/nM | Ki/nM | IC50/nM | Ki/nM |
| thalamus | 831 | 86 | 1455 | 79 | 485 | 50 | 888 | 48 |
| striatum | 887 | 84 | 1238 | 62 | 250 | 24 | 812 | 40 |
| presubiculum | 1080 | 137 | 1890 | 128 | 286 | 37 | 829 | 58 |