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. 2020 Jul 31;63(17):9484–9499. doi: 10.1021/acs.jmedchem.0c00683

Table 2. Direct Comparison between Inhibition Constant (Ki) and IC50 Values for 3b and 3e.

  3b
3e
  [3H]naloxone
[3H]DAMGO
[3H]naloxone
[3H]DAMGO
region IC50/nM Ki/nM IC50/nM Ki/nM IC50/nM Ki/nM IC50/nM Ki/nM
thalamus 831 86 1455 79 485 50 888 48
striatum 887 84 1238 62 250 24 812 40
presubiculum 1080 137 1890 128 286 37 829 58