Fig. 1. The Microphysiology Systems Database (MPS-Db) is key for the development and application of MPS. The MPS-Db is a web-based system that aggregates experimental MPS data, and preclinical and clinical data from various databases enabling the analysis of MPS experimental data in the context of pre-clinical and clinical information. Sources of downloadable information are found as summary text, metadata, raw or processed data from in vitro, pre-clinical animal trials or patient derived clinical/post-marketing sources. The linked data collected at this step become critical when interpreting in vitro MPS results in the context of animal and human in vivo findings. Tools have been built into the MPS-Db to enable the assessment of the reproducibility and transferability of MPS experimental models, and computational models are being developed to enable the utilization of MPS experimental models for understanding mechanisms of disease, compound toxicity, and predicting PK behavior of drugs.