Fig. 5. 18b binding mode and overlay of 8i, 13d and 18b in the MmpL3 binding pocket. (A) Superimposition of 18b (dark cyan), and ICA38 (light brown) in the MmpL3 active site, oriented in a similar way and having a similar binding mode as ICA38. (B) Superimposition of new classes of inhibitors in the MmpL3 active site with similar binding positions as ICA38. ICA38 (light brown), 8i (dark red), 13d (dark grey), and 18b (magenta).