In vitro anti-TB activity of the linker analogues, compounds 2 and 3, isoniazid and ethambutol.
| |||
|---|---|---|---|
| Analogue | MICa (μg mL−1) | MIC (μM) | Clog Pb |
| 21 | 8 | 22.32 | 4.34 |
| 23 | >32 | >85.70 | 3.98 |
| 24 | 32 | 82.38 | 3.13 |
| 27 | >32 | >77.39 | 7.13 |
| 2 | 0.004 | 0.013 | 5.59 |
| 3 | 0.004 | 0.011 | 5.67 |
| Isoniazid | 0.04 | 0.29 | −0.66 |
| Ethambutol | 1 | 4.89 | 0.11 |
a
The lowest concentration of drug reducing at least 90% of bacterial growth by the microplate alamarBlue assay (MABA). The reported MIC values are an average of three individual measurements.
b
Calculated using ChemDraw 16.0.