Activity [MIC (μM)] of the top four active compounds on selected clinical isolates of M. tb and toxicity on Vero cells [IC50 (μM)].
| M. abs (μM) | M. avium (μM) | M. tb MIC (μM) | IC50 (μM) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| V4207/DS | V2475/MDRa | KZN494/MDRa | R506/XDRb | TF274/XDRb | Vero cells | SIc | |||
| 8i | >159 | >159 | 9.97 | 9.97 | 9.97 | 4.98 | 4.98 | 39.87 | 4 |
| 13c | >227 | >227 | 7.11 | 7.11 | 7.11 | 3.55 | 3.55 | ≥227 | ≥32 |
| 13d | >209 | >209 | 6.55–13.10 | 6.55 | 6.55–13.10 | 3.27 | 3.27 | ≥419 | ≥64 |
| 18b | >157 | >157 | 9.82 | 19.64 | 9.82 | 4.91–9.82 | 4.91 | 9.82 | 1 |
a
Resistant to isoniazid and rifampin.
b
Resistant to isoniazid, rifampin, levofloxacin, ofloxacin, and kanamycin.
c
Selectivity index (SI) = IC50(Vero)/MIC.