Fig. 1.

Higher SERINC2 expression correlates with glioma malignancy. a, b Higher expression of SERINC2 mRNA was found in GBM than in low-grade gliomas and normal brain tissues in the TCGA datasets (a) and GSE16011 (b). c, e, g In normal brain cortex tissues, SERINC2 protein was not detectable in glial cells. d One of the 3 LGG cases presented with a medium level of SERINC2 staining, and 2 of the 3 LGG cases were not detectable. f, h Seven of the 8 cases of GBM with SERINC2 examined showed positive SERINC2 staining (4 low, 2 medium, and 1 high), and 1 case presented as not detectable. **** P < 0.0001; *** P < 0.001; ** P < 0.01; * P < 0.05