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. 2020 Jul 8;70(10):1521–1532. doi: 10.1007/s12031-020-01620-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — PPI network construction and hub gene selection in correlation genes. a A total of 564 nodes and 2801 edges were mapped of the copositive and conegative correlation genes in the PPI network. b, c The top 10 genes as ranked by “connectivity degree” in the PPI network were identified as hub genes, including CDC20, FN1, AURKB, AURKA, KIF2C, BIRC5, CCNB2, UBE2C, CCNA2, and CENPE (b), and the PPI network of hub genes was created (c). All of the hub genes positively correlated with SERINC2 (d)