Table 1.
[18F]AlF-mNOTA-GZP tumour uptake from PET-CT/MRI-defined volumes of interest (VOI) from individual mice bearing either CT26 or MC38 tumours subjected to ICI treatment. Data are shown as mean %ID/g ± S.D. of control groups, treatment responders (TR) across individual treatment arms, and all treatment non-responders (TNR) (n = 5–10 mice/group; *P < 0.05; **P < 0.01 comparing TR to TNR, $P < 0.05; $$P < 0.01 comparing TR to control)
| [18F]AlF-mNOTA-GZP tumour uptake | ||
|---|---|---|
| CT26 | MC38 | |
| Control | 0.23 ± 0.06 | 0.62 ± 0.14 |
| Treatment responders (TR) | ||
| αPD1 | 0.42 ± 0.09*$ | 0.98 ± 0.17*$ |
| αCTLA4 | 0.58 ± 0.24*$ | 0.94 ± 0.21*$ |
| αPD1 + αCTLA4 | 0.55 ± 0.10**$$ | 1.01 ± 0.24*$$ |
| αOX40 | 0.53 ± 0.14*$ | 0.98 ± 0.07**$$ |
| αPD1 + αOX40 | 0.59 ± 0.24*$ | 1.09 ± 0.06**$$ |
| αTIM3 | 0.22 ± 0.02 | 1.16 ± 0.34*$ |
| αPD1 + αTIM3 | 0.21 ± 0.05 | 1.02 ± 0.25*$ |
| αLAG3 | 0.24 ± 0.02 | 0.90 ± 0.13*$ |
| αPD1 + αLAG3 | 0.17 ± 0.04 | 0.92 ± 0.18*$ |
| Treatment non-responders (TNR) | 0.19 ± 0.06 | 0.77 ± 0.06 |