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. 2020 Jun 8;22(5):1333–1341. doi: 10.1007/s11307-020-01511-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — SPECT/CT imaging with [¹¹¹In]1. a, b Representative SPECT/CT image of a mouse injected with [¹¹¹In]1 at 6 h.p.i. (a) and 24 h.p.i. (b). The dotted lines indicate field of view of SPECT images. c Concentration of activity in tumor ROIs from SPECT images in kBq/ml, n = 6. d Activity in tumor, normalized injected dose tumor uptake %ID (n = 6). e TBR (tumor to heart) from SPECT signal, n = 6. f Adjacent cryosections from a dissected tumor. From top to bottom: autoradiography, NIRF imaging, and TUNEL staining. * for p < 0.05; ** for p < 0.01.