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. 2020 Apr 13;22(5):1218–1225. doi: 10.1007/s11307-020-01496-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Relative tumor volume in nude mice where V(0) is the tumor volume before treatment and V(t) is the tumor volume at the end of treatment. Six animals are unaccounted in this graph since their xenografts were not measurable at the beginning of the treatment. b % Body weight of mice with a subcutaneous SKOV-3 xenograft during treatment with targeted anticancer drugs (dashed line) and corresponding vehicle controls (solid line), considering the weight at the start of treatment as 100 %. Results are expressed as mean ± SEM. Statistically significant differences compared with controls are indicated with *P < 0.05.