Table 2.

Folate supplementation trials in hyperhomocysteinemia and cardiovascular health

Source	Study type	No. of pts	Mean age (years)	Population	Mean homocysteine (µmol/L)	Benefit
Clarke et al. (1998) [6]	Meta-analysis	1114	52	Varied	12	Yes
Kotwal et al. (2015) [81]	Randomized controlled trial	12,000	Not reported	Indian Soldiers at high altitudes	8.2	Yes
Lonn et al. (2006) [82]	Randomized controlled trial	5,522	68.85	Vascular disease (coronary, cerebrovascular, peripheral vascular)	12.2	No
Armitage et al. (2010) [83]	Randomized controlled trial	12,064	64	Previous MI	13	No
Zhou et al. (2011) [84]	Meta-analysis	44,841	Varied by trial. Means ranged from 48.5–65.8	Cardiovascular events	Did not study	No