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. 2020 Aug 20;21(9):3704–3712. doi: 10.1021/acs.biomac.0c00812

Figure 1.

Figure 1

Preparation of TLR7/8a NPs. (a) N3-PEG–PLA block copolymers can be modified by alkyne-azide “click” chemistry with either a mannose analog or a potent TLR7/8a. (b) Physical mixing of modified PEG–PLA with different termini at various ratios with unmodified PEG–PLA enables simple manufacturing of the nanoparticles by nanoprecipitation with control of surface presentation of the conjugated moieties.