Fig. 1.

Non-synonymous substitutions in the Spike and Nucleocapsid proteins of SARS-CoV-2 in South America. A. Non-synonymous substitution sites in the S protein. Blue bars represent the genomes with conserved positions, red bars represent the genomes with substitution at the indicated site (at least one genome per site). B. Non-synonymous substitutions in the N. Blue bars represent the genome with conserved positions, red bars represent the genomes with substitution at the indicated site (at least one genome). Green bars represent the number of genomes with undetermined amino acids at the indicated site. Black arrows show substitutions found in the 43 Colombian genomes generated in this study. The location of the substitutions was estimated based on the reference genome NC_045512.2. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)