Fig. (3).

Safety evaluation and comparison for drug interactions. D; All participants were divided into four groups: D1) risk of AED-OD interaction owner, D2) AED-AED inrecation owner, D3) drug inrecation not owner, D4) control group. E; All participants were divided into five groups: E1) risk of AED-OD interaction owner, E2) AED-AED inrecation owner, E3) drug inrecation not owner in monotherapies, E4) drug inrecation not owner in polytherapies, E5) control group. Control group was added to the each binary and quaternary groups for only BDNF comparisons and user ANOVA test. AED; Antiepileptic Drug NAD; New Antiepileptic Drug, OAD; Old Antiepileptic Drug, OD; Other Drug, Mono; Monotherapy, Poly; Polytherapy, BDNF; Brain-Derived Neurotrophic Factor, SW; Seizure Worry, OQOL; Overall Quality of Life, EWB; Emotional Well-Being, EF; Energy/Fatigue, C; Cognitive, ME; Medication Effects, SF; Social function, OS; Overall score.