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. 2020 Jan 29;69(10):1807–1817. doi: 10.1136/gutjnl-2018-317505

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Mesolimbic reward gene expression in dams and offspring. mRNA levels of (A) dam nucleus accumbens (NAc) tyrosine hydroxylase (TH) at end of lactation, (B) dam ventral tegmental area (VTA) mu-opioid receptor at end of lactation. (C) Male offspring VTA dopamine transporter (DAT) at weaning. (D) Male offspring VTA DAT at age 18 weeks. (E) Male offspring NAc D2 receptor at age 18 weeks. (F) Female offspring NAc mu-opioid receptor at weaning. (G) Female offspring NAc D2 receptor at weaning. (H) Female offspring VTA TH at weaning. (I) Female offspring NAc DAT at age 18 weeks. Values are mean±SEM. Superscripts indicate significant difference between groups; ^*p<0.05; ^**p<0.01. Obese-APM, obese aspartame (n=7 dams, n=9 M and 8 F offspring); obese-STV, obese stevia (n=7 dams, n=7 M and F offspring); obese-WTR, obese control (n=6 dams, n=5 M and F offspring).

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