Skip to main content
letter
. 2019 Nov 20;69(10):1893–1895. doi: 10.1136/gutjnl-2019-320073

Table 1.

Multivariate analysis for RFS and OS

Covariates RFS OS
Before IPTW-adjustment After IPTW-adjustment Before IPTW-adjustment After IPTW-adjustment
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Solitary
 LR versus LT 3.79 (1.93 to 7.46) <0.001 3.66 (1.80 to 7.44) <0.001 2.33 (1.10 to 4.91) 0.027 1.62 (0.74 to 3.55) 0.226
 LA versus LT 9.56 (5.11 to 17.89) <0.001 10.28 (5.22 to 20.23) <0.001 6.42 (3.34 to 12.31) <0.001 6.07 (3.13 to 11.75) <0.001
 LA versus LR 2.52 (1.60 to 3.98) <0.001 2.81 (1.75 to 4.50) <0.001 2.76 (1.55 to 4.92) <0.001 3.74 (2.00 to 7.02) <0.001
Multiple
 LR versus LT 7.94 (3.19 to 19.75) <0.001 12.40 (4.60 to 33.44) <0.001 5.56 (2.31 to 13.36) <0.001 4.04 (1.78 to 9.16) <0.001
 LA versus LT 6.04 (2.36 to 15.44) <0.001 7.14 (2.47 to 20.67) <0.001 2.38 (0.92 to 6.18) 0.075 1.79 (0.71 to 4.52) 0.219
 LA versus LR 0.76 (0.40 to 1.46) 0.409 0.58 (0.29 to 1.14) 0.115 0.43 (0.20 to 0.90) 0.025 0.44 (0.20 to 0.98) 0.043
Operation
 LT: multiple versus solitary 1.27 (0.46 to 3.49) 0.649 0.75 (0.25 to 2.25) 0.605 1.43 (0.56 to 3.66) 0.461 1.56 (0.65 to 3.79) 0.322
 LR: multiple versus solitary 2.65 (1.48 to 4.74) 0.001 2.53 (1.46 to 4.38) <0.001 3.40 (1.77 to 6.56) <0.001 3.90 (1.94 to 7.84) <0.001
 LA: multiple versus solitary 0.80 (0.44 to 1.45) 0.458 0.52 (0.28 to 0.96) 0.035 0.53 (0.27 to 1.04) 0.065 0.46 (0.22 to 0.96) 0.038
Gender (male) 1.99 (1.14 to 3.47) 0.016 2.65 (1.40 to 5.03) 0.003
Aetiology
 HCV versus HBV 0.57 (0.26 to 1.26) 0.164 0.65 (0.28 to 1.52) 0.318 0.81 (0.34 to 1.95) 0.643 0.93 (0.38 to 2.27) 0.880
 Others versus HBV 1.72 (1.05 to 2.80) 0.031 1.80 (1.06 to 3.06) 0.029 2.47 (1.43 to 4.27) 0.001 2.21 (1.21 to 4.04) 0.010
 Others versus HCV 3.03 (1.25 to 7.35) 0.014 2.78 (1.07 to 7.21) 0.035 3.03 (1.15 to 8.02) 0.025 2.37 (0.86 to 6.48) 0.094
In(AFP) (ng/mL) 1.09 (1.00 to 1.18) 0.039 1.08 (0.99 to 1.18) 0.078
ALBI score 1.35 (1.03 to 1.76) 0.031 1.37 (1.04 to 1.82) 0.027 1.51 (1.12 to 2.02) 0.006 1.35 (1.00 to 1.83) 0.051
Tumour size (cm) (3–5 vs ≤3) 1.43 (0.97 to 2.11) 0.075

Variables that achieved significance at the 0.1 level in the univariate Cox proportional hazards (PH) model were included in the multivariate analysis. Statistical analyses were performed using R V.3.5.2, and p<0.05 was considered statistically significant.

AFP, α-fetoprotein; ALBI, albumin-bilirubin; OS, overall survival; PH, proportional hazards; RFS, recurrence-free survival.