Table 4.
PET/computed tomography versus PET/MRI
| PET/CT | PET/MRI | |||||||
|---|---|---|---|---|---|---|---|---|
| First author | Site | Analysis | Sensitivity (%; 95 CIs) | Specificity (%; 95 CIs) | Accuracy (%; 95 CIs) | Sensitivity (%; 95 CIs) | Specificity (%; 95 CIs) | Accuracy (%; 95 CIs) |
| Sawicki | All | L | 96 | 89 | 95 | 100 | 89 | 99 |
| Sawicki | All | P | 100 | – | – | 100 | – | – |
| Melsaether | All | P | 97A,B (88–99) | 77A–82B (64–91) | – | 100A,B (92–100) | 86C–90D (76–95) | – |
| Catalano | Alla | P | – | – | 75 | – | – | 98b |
| Botsikas | All | L | 77 (67–85) | 98 (97–99)c | – | 89 (81–94)d | 96 (94–98) | – |
| Botsikas | Alle | P | 69 (39–90) | 100 (93–100) | – | 85 (54–97) | 97 (89–99) | |
| Grueneisen | Axillary LNs | P | 78 (52–94) | 94 (79–99) | 88 | 78 (52–94) | 90 (74–98) | 86 |
| Melsaether | Axillary LNs | P | 88A,B (64–99) | 95A,B (88–98) | – | 88D–100C (69–97) | 95C,D (88–98) | – |
| Botsikas | Axillary LNs | L | 81 (67–90) | 92 (85–96) | – | 85 (72–93) | 89 (82–94) | – |
| Botsikas | Axillary LNs | P | 83 (68–91) | 76 (58–89) | – | 87 (73–95) | 68 (49–82) | – |
| Botsikas | Internal mammary LNs | L | 90 (54–99) | 100 (97–100) | – | 90 (54–99) | 100 (97–100) | – |
| Botsikas | Internal mammary LNs | P | 89 (51–99) | 100 (94–100) | – | 89 (51–99) | 100 (94–100) | – |
| Botsikas | Mediastinal LNs | L | 100 (52–100) | 100 (94–100) | – | 100 (52–100) | 100 (94–100) | – |
| Botsikas | Mediastinal LNs | P | 100 (52–100) | 100 (94–100) | – | 100 (52–100) | 100 (94–100) | – |
| Catalano | Bone | P | 85 (70–96) | – | – | 96 (87–100) | 99 (96–100) | – |
| Melsaether | Bone | L | 87B–99A (79–100) | – | – | 95D–98C (90–100) † | – | – |
| Melsaether | Bone | P | 96A,B (84–100) | 97A–100B (90–100) | – | 100C,D (91–100) | 100C,D (93–100) | – |
| Pujara | Bone | P | 94 | – | – | 100 | – | – |
| Botsikas | Bone | L | 69 (48–85) | 100 (97–100) ‡ | – | 92 (73–99) † | 95 (90–98) | – |
| Botsikas | Bone | P | 67 (31–91) | 100 (94–100) | – | 89 (51–99) | 97 (89–99) | – |
| Melsaether | Liver | L | 70B–75A (54–87) | – | – | 80D–100C (66–100) † | – | – |
| Melsaether | Liver | P | 73A,B (50–88) | 100A,B (95–100) | – | 91D–100C (78–100) | 98C–100D (92–100) | – |
| Pujara | Liver | P | 86 | – | – | 100 | – | – |
| Melsaether | Distant LNs | L | 85B–95A (72–99) | – | – | 92D–95C (80–99) | – | – |
| Melsaether | Distant LNs | P | 82A–91B (66–95) | 95B–98A (88–100) | – | 91D–100C (78–100) | 98C,D (90–100) | – |
| Pujara | Distant LNs | P | 100 | – | – | 100 | – | – |
| Botsikas | Contralateral BC | L | 25 (1–78) | 99 (92–100) | 100 (40–100) | 99 (92–100) | ||
| Botsikas | Contralateral BC | P | 33 (2–87) | 99 (92–100) | 100 (31–100) | 99 (92–100) | ||
| Melsaether | Lung | L | 96B–100A (79–100) | – | – | 74D–87C (53–96) | – | – |
| Melsaether | Lung | P | 100A,B (74–100) | 80A–82B (71–90) | – | 83D–100C (62–100) | 89C–91D (81–96) ‡ | – |
| Melsaether | Pleura | L | 100A,B (80–100) | – | – | 100A,B (80–100) | – | – |
| Melsaether | Pleura | P | 100A,B (74–100) | 100A,B (95–100) | – | 100C,D (74–100) | 100C,D (95–100) | – |
| Melsaether | Brain | L | – | – | – | 93D–100C (70–100) | – | – |
A, reader 3 (PET/CT); B, reader 4 (PET/CT); C, reader 1 (PET/MRI); CI, confidence interval; CT, computed tomography; D, reader 2 (PET/MRI); L, lesion level; LNs, lymph nodes; P, patient level.
a
Staging performance.
b
Significantly higher accuracy.
c
Significantly higher specificity.
d
Significantly higher sensitivity.
e
Patients with bone, liver, pulmonary, mediastinal, pleural and thoracic wall metastases.