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Lipid partitioning: model of determinants of tissue drug distribution and apparent binding for simple lipid [concentration of drug in fat (Cfat)] to aqueous (Cw) partitioning. The partition coefficient Kp = Cfat/Cw. For equilibrium dialysis, the total tissue homogenate concentration CT = Cw.Fw + Cfat.Ffat, in which Fw and Ffat are the fractional aqueous and fat contents.
