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Dex activates mPXR and hPXR. (A and B) Western blot and quantification of mPXR downstream proteins from vehicle- or Dex-treated mice livers. Data are expressed as mean ± S.D. (n = 3). *P < 0.05; **P < 0.01 compared with the vehicle group. (C) Dual-luciferase reporter gene assay was used to determine the effect of RIF or Dex on hPXR activation in HEK293T cells. Data are expressed as mean ± S.D. (n = 5). **P < 0.01; ***P < 0.001; ****P < 0.0001 compared with the control group.
