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. 2020 Jun 4;17(7):2398–2410. doi: 10.1021/acs.molpharmaceut.0c00155

Figure 6.

Figure 6

Binding pocket in MRP2. (A) Inhibitors in scaffold 2 reach into the sub-pocket formed by Asn477, Val546, Ser594, Met595, and Met598, while the substrate, CDCF (in yellow) or (B) noninteracting compounds in scaffold 2 do not extend into the sub-pocket.